FLUMAZENIL ![]() (flu-ma'ze-nil) ![]() Mazicon ![]() Classifications: benzodiazepine antagonist; Therapeutic: benzodiazepine antidote Pregnancy Category: C |
0.1 mg/mL injection
Antagonizes the effects of benzodiazepine on the CNS, including sedation, impairment of recall, and psychomotor impairment. Does not reverse the effects of opioids.
Reverses the action of a benzodiazepine.
Reversal of sedation induced by benzodiazepine for anesthesia or diagnostic or therapeutic procedures and through overdose.
Seizure disorders, alcohol intoxication, hepatic encephalopathy, facilitation of weaning from mechanical ventilation.
Hypersensitivity to flumazenil or to benzodiazepines; patients given a benzodiazepine for control of a life-threatening condition; patients showing signs of cyclic antidepressant overdose; seizure-prone individuals; during labor and delivery; pregnancy (category C); children <18 y.
Hepatic function impairment, older adults, lactation, intensive care patients, head injury, anxiety or pain disorder; drug- and alcohol-dependent patients, and physical dependence upon benzodiazepines.
Reversal of Sedation Adult: IV 0.2 mg over 15 sec, may repeat 0.2 mg each min for 4 additional doses or a cumulative dose of 1 mg Benzodiazepine Overdose Adult: IV 0.2 mg over 30 sec, if no response after 30 sec, then 0.3 mg over 30 sec, may repeat with 0.5 mg each min (max: cumulative dose of 3 mg) |
Intravenous PREPARE: Direct: May give undiluted or diluted. If diluted use D5W, Lactated Ringer's, NS. ADMINISTER: Direct for Reversal of Anesthesia: ??Ensure patency of IV before administration of flumazenil, since extravasation will cause local irritation.??Do not give as bolus dose. Give through an IV that is freely flowing into a large vein. Direct for Reversal of Anesthesia or Sedation: |
Assessment & Drug Effects
Patient & Family Education