FENOLDOPAM MESYLATE (fen-ol'do-pam mes'y-late) Corlopam Classifications: non-nitrate vasodilator; dopamine agonist agent; antihypertensive; Therapeutic: non-nitrate vasodilator; antihypertensive Pregnancy Category: B |
10 mg/mL injection
Rapid-acting vasodilator that is a dopamine D1-like receptor agonist. Exerts hypotensive effects by decreasing peripheral vascular resistance while increasing renal blood flow, diuresis, and natriuresis.
Indicated by rapid reduction in BP. Decreases both systolic and diastolic pressures.
Short-term (up to 48 h) management of severe hypertension.
Hypersensitivity to fenoldopam. Avoid concomitant use with beta blockers.
Asthmatic patients; hepatic cirrhosis, portal hypertension, or variceal bleeding; arrhythmias, tachycardia, or angina, particularly unstable angina; elevated IOP; angular-closure glaucoma; hypotension; hypokalemia; acute cerebral infarct or hemorrhage; pregnancy (category B), lactation.
Severe Hypertension Adult: IV 0.10.3 mcg/kg/min by continuous infusion for up to 48 h, may increase by 0.050.1 mcg/kg/min q15min (dosage range: 0.011.6 mcg/kg/min) Child: IV 0.2 mcg/kg/min, may increase to 0.30.5 mcg/kg/min |
Intravenous PREPARE: Continuous for Adult: Dilute to a final concentration of 40 mcg/mL by adding 1 mL (10 mg), 2 mL (20 mg), or 3 mL (30 mg) of fenoldopam to 250, 500, or 1000 mL, respectively, of NS or D5W. Continuous for Child: Dilute to a final concentration of 60 mcg/mL by adding 0.6 mL (6 mg), 1.5 mL (15 mg) or 3 mL (3 mg) of fenoldopam to 100, 250, or 500 mL, respectively, of NS or D5W. ADMINISTER: Continuous for Adult/Child: Give only by continuous infusion; never give a direct or bolus dose. Titrate initial dose up or down no more frequently than q15min. INCOMPATIBILITIES Y-site: Aminophylline, ampicillin, amphotericin B, bumetanide, cefoxitin, dexamethasone, diazepam, fosphenytoin, furosemide, ketorolac, methohexital, methylprednisolone, pentobarbital, phenytoin, prochlorperazine, sodium bicarbonate, thiopental. |
Assessment & Drug Effects