FAMCICLOVIR AND PROBENECID

The renal excretion of drugs similar to famciclovir is reduced by probenecid. Therefore the manufacturers of famciclovir suggest that probenecid may increase levels of penciclovir, the active metabolite of famciclovir, possibly resulting in increased adverse effects.
As yet there seems to be no experimental or clinical evidence to show that this interaction occurs or that it is likely to be clinically important. Consider also aciclovir.
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