The
renal excretion of drugs similar to
famciclovir is reduced by
probenecid. Therefore the manufacturers of
famciclovir suggest that
probenecid may increase levels of
penciclovir, the active
metabolite of
famciclovir, possibly resulting in increased adverse effects.
As yet there seems to be no experimental or
clinical evidence to show that this interaction occurs or that it is likely to be clinically important. Consider also
aciclovir.