PENCICLOVIR
| PENCICLOVIR (pen-cy'clo-vir) Denavir Classifications: antiviral; Therapeutic: antiviral Pregnancy Category: B |
Availability
10 mg/g cream
Action
Antiviral agent active against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). HSV-1 and HSV-2 infected cells phosphorylate penciclovir utilizing viral thymidine kinase. Resulting form of penciclovir competes with viral DNA, thus inhibiting both viral DNA synthesis and replication.
Therapeutic Effect
Inhibits both viral DNA synthesis and replication. Effectiveness is measured in decreased viral load.
Uses
Treatment of recurrent herpes labialis (cold sores).
Contraindications
Hypersensitivity to penciclovir, lactation.
Cautious Use
Pregnancy (category B). Safety and efficacy in children <12 y have not been established. Safety in immunocompromised patients is not established.
Route & Dosage
| Cold Sores Adult: Topical Apply q2h while awake x 4 d |
Administration
Topical- Apply as soon as possible after developing lesion.
- Do not apply to mucous membranes or near the eyes.
- Store at or below 30° C (86° F). Do not freeze.
Adverse Effects (≥1%)
CNS: Headache. Skin: Erythema.Pharmacokinetics
Absorption: Minimally absorbed from cold sore.Nursing Implications
Assessment & Drug Effects
- Monitor the extent of lesions and treatment effectiveness.
Patient & Family Education
- Wash hands before and after application. Avoid contact of drug with eyes.
- Apply sunscreen to lips; may minimize recurrence of lesions.
Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; 
Canadian drug name; 
Prototype drug