(em-e-das'teen di-foom'a-rate)
Classifications: eye preparation; antihistamine, ocular; h1-receptor antagonist;
Therapeutic:ocular antihistamine

Pregnancy Category: B


0.05% ophthalmic solution


Emedastine is a selective antagonist at H1-receptors. It blocks H1-receptors and inhibits histamine-stimulated vascular permeability in the conjunctiva. As a result, emedastine relieves the ocular pruritus associated with allergic conjunctivitis.

Therapeutic Effect

Relieves ocular pruritus related to allergic response to histamine.


Temporary relief of seasonal allergic conjunctivitis.


Hypersensitivity to emedastine.

Cautious Use

Hypersensitivity to other antihistamines, soft contact lenses; pregnancy (category B), lactation. Safety and efficacy in children <3 y are not established.

Route & Dosage

Allergic Conjunctivitis
Adult: Ophthalmic 1 drop in affected eye q.i.d.


  • Wash hands before and after use.
  • Shake well before using. Apply drops in the center of the lower conjunctional sac. Do not touch eyelids with dropper.
  • Gently close eyes for 1–2 min after installation of drops.
  • Wait 10 min after installation of drug before inserting soft lenses into eyes
  • Store in a tightly closed bottle. Protect the solution from light.
  • Do not use if discolored.

Adverse Effects (≥1%)

CNS: Headache. Special Senses: Ocular irritation, mild transient stinging and burning, conjunctival congestion, eyelid edema, eye pain, photophobia, abnormal lacrimation.


Drug: No clinically significant interactions established.


Absorption: Minimal. Half-Life: 3–4 h.

Nursing Implications

Assessment & Drug Effects

  • Monitor for S&S of hypersensitivity to the drug (see Appendix F).
  • Evaluate safety of engaging in hazardous activities since drowsiness is a potential adverse effect.

Patient & Family Education

  • Learn potential adverse responses to emedastine.
  • Eye drops contain benzalkonium chloride, which may damage soft contact lenses. After instillation of drops, wait 10 min before inserting these contact lens into the eye.
  • Contact your physician if symptoms do not start to improve in 2 or 3 d.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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