Benza, Benzalchlor-50, Germicin, Pharmatex , Sabol, Zephiran
Classifications: topical antibiotic; Therapeutic: antibiotic
Pregnancy Category: C
17% concentrate, 1:750 solution, 1:750 tincture/tincture spray
Bactericidal or bacteriostatic action (depending on concentration), probably due to inactivation of bacterial enzyme.
Effective against bacteria, some fungi (including yeasts) and certain protozoa. Generally not effective against spore-forming
Antisepsis of intact skin, mucous membranes, superficial injuries, and infected wounds; also for irrigations of the eye and
body cavities and for vaginal douching. A component of several contact lens wetting and cushioning solutions, and a preservative
for ophthalmic solutions.
Casts, occlusive dressings, anal or vaginal packs, pregnancy (category C), lactation.
Irrigation of body cavities.
Route & Dosage
|Minor Wounds or Preoperative Disinfection
Adult: Topical 1:750 tincture or spray
Preoperative Disinfection of Denuded Skin and Mucous Membranes
Adult: Topical 1:10,0001:2000 solution
Adult: Topical 1:5000 solution
Urinary Bladder Irrigation
Adult: Topical 1:20,0001:5000 solution
Urinary Bladder Instillation
Adult: Topical 1:40,0001:20,000 solution
Irrigation of Deep Infected Wounds
Adult: Topical 1:20,0001:3000 solution
Adult: Topical 1:50001:2000 solution
Sterile Storage of Instruments, Thermometers, Ampules
Adult: Topical 1:750 solution
- Use sterile water for injection as diluent for aqueous solutions to be instilled in wounds or body cavities. For other uses,
fresh sterile distilled water is used.
- Do not use tap water (especially hard water) because it may reduce antibacterial potency of benzalkonium chloride.
- Irrigate eyes immediately and repeatedly with water if medication solution stronger than 1:5000 enters eyes; see a physician
- Rinse first with water, then with 70% alcohol, before applying benzalkonium for preoperative skin preparation. Avoid
pooling or prolonged contact of solution with skin.
- Note: Detergent action is antagonized by pus and other organic matter, and by soap substitutes. If these agents have been used,
rinse skin thoroughly with water, dry, and then apply benzalkonium.
- Consult physician about proper dilution of solutions used on denuded skin or inflamed or irritated tissues.
- Store at room temperature, preferably between 15°30° C (59°86° F) in airtight container, protected
Adverse Effects (≥1%) Body as a Whole:
Few or no toxic effects in recommended dilutions. Skin: Erythema
, local burning, hypersensitivity reactions.
Assessment & Drug Effects
- Monitor wounds carefully. Report increasing signs of infection or lack of healing.