A small rise in
serum digoxin levels may occur in patients also given
omeprazole, pantoprazole, rabeprazole and possibly
lansoprazole. However, these changes are thought to be within the normal variations of
digoxin levels and so are not considered clinically significant. However, one patient developed
digoxin toxicity 3 months after starting to take
omeprazole.
No action needed. The isolated case of
toxicity seems unlikely to be generally significant.