Didanosine (DDI, Videx); Antiretroviral,
Nucleoside Analog Reverse Transcriptase Inhibitor; Cap, DR and EC: 125, 200, 250, 400 mg
Powd pkt, buffered: 100, 167, 250 mg
Susp: 10 mg/mL or 20 mg/mL when admixed with antacid (single strength or double strength)
Tab, chew/buffered: 25, 50, 100, 150, 200 mg;
<90 days: 100 mg/m2/day PO q12h
90 days to 13 yrs:
180-300 mg/m2/day PO bid
>13 yrs:
<60 kg: 125 mg q12h (tablets or powder packets) or 167 mg q12h (oral susp)
>60 kg: 200 mg q12h (tablets or powder packets) or 250 mg q12h (oral susp) or 400 mg qd (DR cap)
OR >35 kg: 5-10 mg/kg/day PO q12h
Children >1 yr should take drug as two chewable tablets or as powder packets or as suspension to ensure that adequate buffering is obtained; must be
taken on an empty stomach. Peripheral
neuropathy,
pancreatitis, headache.