Omeprazole increases the AUC of 3,4-dehydro-cilostazol (a
metabolite with 4 to 7 times the activity of cilostazol) by about 70%. Lansoprazole may interact similarly.
The US manufacturers suggest that the dose of
cilostazol should be halved when given with
omeprazole, while the UK manufacturers suggest that concurrent use should be avoided.