CICLOPIROX OLAMINE
| CICLOPIROX OLAMINE (sye-kloe-peer'ox) Loprox, Penlac Nail Lacquer Classifications: antifungal antibiotic; Therapeutic: antifungal antibiotic Pregnancy Category: B |
Availability
1% cream, ointment; 8% nail lacquer; 1% shampoo
Action
Synthetic broad-spectrum antifungal agent with activity against pathogenic fungi. Inhibits transport of amino acids within fungal cell, thereby interfering with synthesis of fungal protein, RNA, and DNA.
Therapeutic Effect
Effective against the following organisms: dermatophytes, yeasts, some species of Mycoplasma and Trichomonas vaginalis, and certain strains of gram-positive and gram-negative bacteria.
Uses
Topically for treatment of tinea cruris and tinea corporis (ringworm) due to Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis, and for tinea (pityriasis) versicolor due to M. furfur; also cutaneous candidiasis (moniliasis) caused by Candida albicans. Nail lacquer indicated for onychomycosis of fingernails and toenails due to T. rubrum; seborrheic dermatitis of the scalp.
Contraindications
Hypersensitivity to ciclopirox olamine or to any component in the formulation; concurrent administration of corticosteroid therapy. Safe use in children <10 y not established.
Cautious Use
Type 1 diabetic patient; history of seizure disorder; immunosuppression; pregnancy (category B); lactation.
Route & Dosage
| Tinea Adult: Topical Massage cream into affected area and surrounding skin twice daily, morning and evening. Onychomycosis Adult: Topical Paint affected nail(s) under the surface of the nail and on the nail bed once daily at bedtime (at least 8 h before washing). After 7 d, remove lacquer with alcohol and remove or trim away unattached nail. Continue up to 48 wk. Seborrheic Dermatitis Adult: Topical Wet hair and apply approximately 1 tsp (5 mL) to the scalp (may use up to 10 mL for long hair), leave on scalp for 3 min, then rinse. Repeat treatment twice/wk x 4 wk, with a min 3 d between applications. |
Administration
- Wash hands thoroughly before and after treatments.
- Consult with physician about specific procedure for cleansing the skin before medication is applied. Regardless of method used, dry skin thoroughly before drug application.
- Avoid occlusive dressing, wrapping, or clothing over site where cream is applied.
- Store at 15°–30° C (59°–86° F) unless otherwise directed.
Adverse Effects (≥1%)
Skin: Irritation, pruritus, burning, worsening of clinical condition.Interactions
Drug: No clinically significant interactions established.Pharmacokinetics
Absorption: 1.3% absorbed through intact skin. Distribution: Distributed to epidermis, corium (dermis), including hair and hair follicles and sebaceous glands; not known if crosses placenta or is distributed into breast milk. Elimination: Excreted primarily by kidneys. Half-Life: 1.7 h.Nursing Implications
Assessment & Drug Effects
- Monitor for therapeutic effectiveness. Tinea versicolor generally responds to drug treatment in about 2 wk. Tinea pedis ("athlete's foot"), tinea corporis (ringworm), tinea cruris ("jock itch"), and candidiasis (moniliasis) require about 4 wk of therapy.
Patient & Family Education
- Use medication for the prescribed time even though symptoms improve.
- Report skin irritation or other possible signs of sensitization. A reaction suggestive of sensitization warrants drug discontinuation.
- Do not use occlusive dressings or wrappings.
- Avoid contact of drug in or near the eyes.
- Wear light clothing and footwear that will allow ventilation. Loose-fitting cotton underwear or socks are preferred.
Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; 
Canadian drug name; 
Prototype drug