Chloroquine reduces the bioavailability of
praziquantel, which would be expected to reduce its
efficacy in systemic worm infections such as schistosomiasis. Note that
hydroxychloroquine may interact similarly.
It has been suggested that an increased dosage of
praziquantel should be considered in the presence of chloroquine, particularly in anyone who does not respond to initial treatment with
praziquantel. This interaction is not of importance when
praziquantel is used for intestinal worm infections (where its action is a local effect on the worms in the gut).
Ciclosporin (Cyclosporine)