PRAZIQUANTEL (pray-zi-kwon'tel) Biltricide Classifications: anthelmintic; Therapeutic: anthelmintic Prototype: Mebendazole Pregnancy Category: B |
600 mg tablets
Synthetic agent with broad-spectrum anthelmintic activity against all developmental stages of schistosomes and other trematodes (flukes) and against cestodes (tapeworm). Increases permeability of parasite cell membrane to calcium. Leads to immobilization of their suckers and dislodgment from their residence in blood vessel walls.
Active against all developmental stages of schistosomes, including cercaria (free-swimming larvae). Activity against other trematodes (flukes) not fully understood; activity against cestodes (tapeworms) not clear but may be similar to that against schistosomes.
All stages of schistosomiasis (bilharziasis) caused by all Schistosoma species pathogenic to humans. Other trematode infections caused by Chinese liver fluke.
Lung, sheep liver, and intestinal flukes and tapeworm infections.
Hypersensitivity to drug; ocular cysticercosis. Safety in children <4 y is not established; women should not breast feed on day of praziquantel therapy or for 72 h after last dose of drug.
Hepatic disease; cardiac arrhythmias; pregnancy (category B).
Schistosomiasis Adult/Child (>4 y): PO 60 mg/kg in 3 equally divided doses at 46 h intervals on the same day, may repeat in 23 mo after exposure Other Trematodes Adult/Child (>4 y): PO 75 mg/kg in 3 equally divided doses at 46 h intervals on the same day Cestodiasis (Adult or Intestinal Stage) Adult: PO 1020 mg/kg as single dose Cestodiasis (Larval or Tissue Stage) Adult: PO 50 mg/kg in 3 divided doses/d for 14 d |
Be mindful that selected drugs may interfere with stool studies for ova and parasites: iron, bismuth, oil (mineral or castor), Metamucil (if ingested within 1 wk of test), barium, antibiotics, antiamebic and antimalarial drugs, and gallbladder dye (if administered within 3 wk of test).
Assessment & Drug Effects
Patient & Family Education