CANAGLIFLOZIN

(KAN a gli FLOE zin) Brand: Invokana

What is the most significant information I must know about canagliflozin?

• You must not use canagliflozin if you have severe kidney malady, if you are on dialysis, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin). Canagliflozin is not for treating type 1 diabetes.

What is canagliflozin?

• Canagliflozin is an oral diabetes medication that helps control blood sugar levels. Canagliflozin works by helping the kidneys get rid of glucose from your bloodstream.

• Canagliflozin is used together with diet and exercice to treat type 2 diabetes. Canagliflozin is not for treating type 1 diabetes.

• Canagliflozin may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking canagliflozin?

• You must not use canagliflozin if you are allergic to it, or if you have:

· kidney malady (or if you are on dialysis); or

· if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

• To create certain canagliflozin is safety for you, speak your doctor if you have:

· kidney disease;

· liver disease;

· low blood pressure;

· an electrolyte imbalance (such as tall levels of potassium in your blood); or

· tall cholesterol levels.

• FDA pregnancy category C. It is not known whether canagliflozin will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

• It is not known whether canagliflozin passes into breast milk or if it could harm a nursing child. You must not breast-feed while using this medicine.

• Side effects may be more likely to occur in older adults.

• Do not give this medicine to anyone under 18 years old without medical advice.

How must I take canagliflozin?

• Canagliflozin is generally taken once for day. Follow all directions on your prescription label. Your doctor may occasionally change your doze to create certain you get the excellent results. Do not take this medication in larger or less amounts or for longer than recommended.

• Canagliflozin works excellent if you take it till your first meal of the day.

• Your blood sugar will need to be checked often, and you may need another blood trials at your doctor's office.

• You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than normal.

• Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, famine, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always hold a source of sugar with you in case you have low blood sugar. Sugar sources include fruit juice, heavy candy, crackers, raisins, and non-diet soda. Be certain your family and close friends know how to help you in an emergency.

• If you have severe hypoglycemia and can't ate or drink, use a glucagon injection. Your doctor can prescribe a glucagon abnormal injection kit and speak you how to use it.

• Also watch for signs of tall blood sugar (hyperglycemia) such as heighten thirst, heighten urination, famine, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.

• Check your blood sugar carefully during times of stress, travel, diseases, surgery or medical abnormal, vigorous exercice, or if you drink alcohol or skip meals. These things can affect your glucose levels and your doze needs may also change. Do not change your medicine doze or schedule without your doctor's advice.

• This medicine can reason positive results with determined lab trials for glucose (sugar) in the urine. Speak any doctor who treats you that you are using canagliflozin.

• Canagliflozin is only part of a treatment program that may also include diet, exercice, weight control, blood sugar testing, and particular medical care. Follow your doctor's instructions very closely.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

What must I avoid while taking canagliflozin?

• Avoid getting up too quick from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

What are the possible side effects of canagliflozin?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have:

· a light-headed feeling, like you might pass out;

· pain or burning when you urinate;

· signs of a genital infection (penis or vagina), such as pain, burning, itching, or discharge;

· tall potassium (slow heart course, weak pulse, muscle weakness, tingly feeling);

· swelling, rapid weight gain, few or no urinating; or

· feeling very thirsty or hot, being unable to urinate, hard sweating, or hot and dry skin.

• General side effects may include:

· urinating more than normal;

· nausea; or

· constipation.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect canagliflozin?

• Speak your doctor about all medicines you use, and those you start or stop using during your treatment with canagliflozin, especially:

· digoxin, digitalis;

· rifampin;

· ritonavir;

· a diuretic or "water pill";

· heart or blood pressure medication; or

· seizure medication--phenobarbital, phenytoin.

• This list is not complete. Another drugs may interact with canagliflozin, including prescription and over-the-counter medicines, vitamins, and herbal commodity. Not all possible interactions are listed in this medicine manual.

Where can I get more information?

• Your pharmacist can provide more information about canagliflozin.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.