Isoniazid reduces the clearance of both
diazepam and
triazolam. Some increase in their effects would be expected.
The degree of sedation will depend on the individual patient. However, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks. Reduce the benzodiazepine dose as necessary. Clotiazepam and
oxazepam appear to be non-interacting alternatives.