The
serum levels of adinazolam,
alprazolam, chlordiazepoxide, clobazam, clorazepate,
diazepam, flurazepam, nitrazepam,
triazolam,
zaleplon,
zolpidem (and probably halazepam and prazepam) are raised by
cimetidine, but normally this appears to be of little or no
clinical importance, and only the occasional patient may experience an
increase in effects (sedation). Clotiazepam,
lorazepam, lormetazepam,
oxazepam and
temazepam are not normally affected by
cimetidine. Famotidine,
nizatidine and ranitidine do not interact with most benzodiazepines, except possibly
triazolam. The picture with
midazolam is somewhat confused.
In general no clinically significant interaction occurs, but note that individual patients may rarely experience increased sedation.