Fluconazole increases the AUC and maximum
plasma levels of
fluvastatin by 84% and 44%, respectively.
The
clinical relevance of the modest changes in
fluvastatin levels with
fluconazole is unclear. However, because of the potentially serious reactions that can result, any patient given
fluvastatin, with
fluconazole (or miconazole, including the oral gel) should be told to report any unexplained muscle pain, tenderness or weakness.