AZOLES AND STATINS - ATORVASTATIN

The AUC of atorvastatin is raised by 150% by itraconazole. Rhabdomyolysis has been seen when atorvastatin and fluconazole have been given.
Because of the potentially serious reactions that can result, any patient given atorvastatin with an azole should be told to report any unexplained muscle pain, tenderness or weakness. Because large increases in atorvastatin levels can occur (most likely with itraconazole or ketoconazole), consider temporarily withdrawing the statin. The manufacturers of voriconazole recommend a dose reduction of atorvastatin (and lovastatin and simvastatin) during concurrent use. For
posaconazole, see Simvastatin or Lovastatin, below.
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