Ketoconazole almost doubles the AUC of
praziquantel, which appears to increase the
incidence of mild adverse effects (headache and
gastrointestinal adverse effects, including nausea and vomiting).
Information is limited, but all
azoles have the potential to interact, to a greater or lesser extent. It may be prudent to be alert for an increase in the adverse effects of
praziquantel, although an increase in
efficacy is also possible.