ATOVAQUONE AND PROGUANIL

(a TOE va kwone and pro GWAHN il) Brand: Malarone, Malarone Pediatric

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What is the most significant information I must know about atovaquone and proguanil?

• You must not use this medicine if you are allergic to atovaquone or proguanil. You must not use this medicine to prevent malaria if you have severe kidney disease.

• Till using this medicine, speak your doctor if you have liver or kidney malady, severe complications from infection with malaria, or uncontrolled vomiting or diarrhea.

• Take atovaquone and proguanil at the same time every day with food or a milky drink.

• If you vomit within 1 hour after taking this medicine, take other doze. If your vomiting continues, call your doctor.

• If you are taking this medication to prevent malaria, start taking it 1 or 2 days till entering an area where malaria is general. Take the medicine each day during your remain and for at least 7 days after you leave. If you stop taking the medication early for any cause, contact a healthcare professional about other form of malaria prevention.

• If you are taking this medication to treat malaria, take the medicine each day for 3 days in a row.

• Take this medicine for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared.

• In addition to taking atovaquone and proguanil, use protective clothing, insect repellents, and mosquito netting near your bed to further prevent mosquito bites that could reason malaria.

• Contact your doctor as soon as possible if you have been exposed to malaria, or if you have a fever or another symptoms of diseases during or after a remain in an area where malaria is common.

• No medicine is 100% effective in treating or preventing malaria. For excellent results, hold using the medicine as directed. Conversation with your doctor if you have fever, vomiting, or diarrhea during your treatment.

What is atovaquone and proguanil?

Atovaquone and proguanil are medications to treat malaria, a malady caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body.

• Parasites that reason malaria typically enter the body through the bite of a mosquito. Malaria is general in areas such as Africa, South America, and Southern Asia.

• The combination of atovaquone and proguanil is used to treat or prevent malaria.

Atovaquone and proguanil may also be used for purposes not listed in this medicine guide.

What must I discuss with my healthcare provider till taking atovaquone and proguanil?

• You must not use this medicine if you are allergic to atovaquone or proguanil. You must not use this medicine to prevent malaria if you have severe kidney disease.

• To create certain you can safely take atovaquone and proguanil, speak your doctor if you have any of these another conditions:

· kidney disease;

· liver disease;

· severe complications from malaria; or

· uncontrolled vomiting or diarrhea.

• FDA pregnancy category C. It is not known whether atovaquone and proguanil will harm an unborn child. Speak your doctor if you are pregnant or plan to become pregnant while using this medication.

Malaria is more likely to reason death in a pregnant woman. If you are pregnant, conversation with your doctor about the risks of traveling to areas where malaria is common.

Atovaquone and proguanil can pass into breast milk and may harm a nursing child. Do not use this medicine without telling your doctor if you are breast-feeding a baby.

Atovaquone and proguanil must not be used to treat malaria in a baby who weighs smaller than 11 pounds, and must not be used to prevent malaria in a baby who weighs smaller than 24 pounds.

How must I take atovaquone and proguanil?

• Take exactly as predesigned by your doctor. Do not take in larger or less amounts or for longer than recommended. Follow the directions on your prescription label.

• Use atovaquone and proguanil regularly to excellent prevent malaria. If you stop using the medicine early for any reason, conversation to your doctor about another forms of malaria prevention.

• Take atovaquone and proguanil at the same time every day with food or a milky drink.

• If you vomit within 1 hour after taking this medicine, take other doze. If your vomiting continues, call your doctor.

• If you are taking this medication to prevent malaria:

· Start taking the medication 1 or 2 days till entering an area where malaria is general. Continue taking the medication each day during your remain and for at least 7 days after you leave the area.

· If you stop taking the medication early for any cause, contact a healthcare professional about other form of malaria prevention.

• If you are taking this medication to treat malaria:

· Take the medication each day for 3 days in a row.

· Take this medicine for the full predesigned length of time. Your symptoms may improve till the infection is completely cleared.

• In addition to taking atovaquone and proguanil, use protective clothing, insect repellents, and mosquito netting near your bed to further prevent mosquito bites that could reason malaria.

• To be certain this medicine is not causing deleterious effects, your liver function will need to be checked with frequent blood trials. Visit your doctor regularly.

• Contact your doctor as soon as possible if you have been exposed to malaria, or if you have fever or another symptoms of diseases during or after a remain in an area where malaria is common.

• No medicine is 100% effective in treating or preventing malaria. For excellent results, hold using the medicine as directed. Conversation with your doctor if you have fever, vomiting, or diarrhea during your treatment.

• Store at room temperature away from moisture and heat.

What happens if I miss a dose?

• Take the missed doze as soon as you remember. Skip the missed doze if it is nearly time for your following scheduled doze. Do not take extra medication to create up the missed dose.

What happens if I overdose?

• Search abnormal medical attention or call the Poison Help line at 1-800-222-1222.

• Overdose symptoms may include stomach discomfort, vomiting, mouth sores, hair loss, light bruising or bleeding, and peeling of the skin on your hands or feet.

What must I avoid while taking atovaquone and proguanil?

• Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of atovaquone and proguanil?

• Get abnormal medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your person, lips, tongue, or throat.

• Call your doctor at once if you have a serious side effect such as:

· severe or uncontrolled vomiting or diarrhea;

· fever, mouth sores;

· problems with speech, balance, or walking;

· severe skin rash;

· nausea, stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); o

· light bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin.

• Smaller serious side effects may include:

· mild stomach pain or upset stomach;

· mild diarrhea;

· headache;

· mild itching;

· weakness; or

· dizziness.

• This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may message side effects to FDA at 1-800-FDA-1088.

What another drugs will affect atovaquone and proguanil?

• Speak your doctor about all another medicines you use, especially:

· a blood thinner such as warfarin (Coumadin);

· rifabutin (Mycobutin);

· rifampin (Rifadin, Rifater, Rifamate, Rimactane);

· tetracycline (Brodspec, Panmycin, Sumycin, Tetracap); or

· metoclopramide (Reglan).

• This list is not complete and another drugs may interact with atovaquone and proguanil. Speak your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal commodity. Do not start a new medicine without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about atovaquone and proguanil.

Remember, hold this and all another medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.

Disclaim: Each effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses external of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way must be construed to indicate that the drug or drug combination is safety, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the help of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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