Fluconazole normally appears not to affect the diabetic
control of most patients taking sulphonylureas, but isolated reports describe hypoglycaemic coma and aggressive behaviour following concurrent use.
Fluconazole may cause marked increases in
plasma levels of
glimepiride, but the significance of this is unclear. Nateglinide
plasma levels may also be increased by
fluconazole, but this did not affect the
control of blood glucose levels.
There is no reason to avoid concurrent use but warn patients to report any unexpected changes in blood glucose levels.