ANTACIDS AND ISONIAZID

The absorption of isoniazid is modestly reduced by aluminium hydroxide (about 25%), less so by magaldrate, and not affected by aluminium/magnesium hydroxide tablets or didanosine chewable tablets (formulated with an antacid buffer).
The clinical importance of the modest reductions in isoniazid levels is uncertain, but it is likely to be small.
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