Classifications: antacid; Therapeutic: antacid
Prototype: Aluminum hydroxide
Pregnancy Category: B with occasional use
540 mg/5 mL suspension
By reducing gastric acidity, stomach pH increases and proteolytic activity of pepsin is inhibited. Reportedly does not produce
alkalosis or acid rebound and is not as likely to produce alterations of bowel function that occur with either aluminum or
magnesium hydroxide alone.
Nonsystemic antacid with true buffering action and high acid-neutralizing capacity.
Symptomatic relief of hyperacidity associated with peptic ulcer, gastritis, peptic esophagitis, and hiatal hernia, particularly
in patients who need to restrict sodium.
Sensitivity to components; hypermagnesia; appendicitis, colostomy, diverticulitis, ileostomy, ulcerative colitis; pregnancy
(category B) with occasional use; children <2 y.
Impaired kidney function, dialysis patients; CHF; biliary cirrhosis, GI obstruction, constipation.
Route & Dosage
Adult: PO 4801080 mg (510 mL suspension or 12 tablets) q.i.d. (max: 20 tablets or 100 mL/d)
- Shake suspension vigorously before pouring. Preferably give between meals and at bedtime.
- Give suspension with sufficient water to ensure passage of drug into stomach.
- Make sure chewable tablets are chewed thoroughly before being swallowed. Give tablet to be swallowed whole with enough water
to ensure prompt swallowing without chewing.
Adverse Effects (≥1%) GI:
or diarrhea (with prolonged use). Urogenital:
Hypermagnesemia (in patients with impaired kidney function).
Will decrease absorption of tetracyclines
Minimally from GI tract. Duration:
Buffering action up to 60 min.
Assessment & Drug Effects
- Question patient about effectiveness of medication in relieving GI distress.
- Lab tests: Check patients on prolonged therapy periodically for electrolyte imbalance (i.e., hypermagnesemia).
Patient & Family Education
- Be aware that, in common with other antacids, magaldrate may cause premature dissolution and absorption of enteric-coated
tablets and interfere with the absorption of oral tetracyclines and other oral medications.
- Do not take other oral drugs, generally, within 12 h of an antacid.