Food increases the bioavailability of eprosartan and losartan, slightly reduces the bioavailability of telmisartan
, and modestly reduces the AUC of valsartan
. Food appears to have little or no effect on the bioavailability of candesartan, irbesartan
, or olmesartan.
None of these changes is likely to be clinically important. The UK manufacturer recommends that eprosartan is given with food, but the US manufacturer suggests that the interaction is not clinically significant.