Symptomatic hypotension may occur if an angiotensin II receptor
antagonist is started in patients taking high-dose diuretics
. Potassium levels may be either increased, decreased or not affected. There is no clinically significant pharmacokinetic inter- action between valsartan
It has been recommended that the dose of diuretic or angiotensin II receptor
antagonist be reduced to begin with, to avoid hypotension. Initially monitor blood pressure and potassium levels.