ANGIOTENSIN II RECEPTOR ANTAGONISTS AND DIURETICS - LOOP DIURETICS

Symptomatic hypotension may occur if an angiotensin II receptor antagonist is started in patients taking high-dose diuretics. Potassium levels may be either increased, decreased or not affected. There is no clinically significant pharmacokinetic inter- action between valsartan and furosemide.
It has been recommended that the dose of diuretic or angiotensin II receptor antagonist be reduced to begin with, to avoid hypotension. Initially monitor blood pressure and potassium levels.
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