ANGIOTENSIN II RECEPTOR ANTAGONISTS AND DIGOXIN

Telmisartan may cause a 13% rise in trough serum digoxin levels and a 50% rise in peak serum levels.
The small increase in the trough levels suggests that the dose of digoxin need not automatically be reduced when telmisartan is started, but consideration should be given to monitoring for digoxin adverse effects such as bradycardia, taking digoxin levels if necessary. Candesartan, eprosartan, irbesartan, losartan, and valsartan appear not to affect digoxin levels.
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