No clinically relevant pharmacokinetic interactions occur between glibenclamide (
glyburide) and candesartan,
telmisartan or
valsartan, or between
tolbutamide and
irbesartan. Losartan and possibly eprosartan may reduce awareness of hypoglycaemic
symptoms.
The
symptoms of hypoglycaemia may be reduced by losartan and possibly other angiotensin II
receptor antagonists. Further study is needed to establish this interaction, but note that this is similar to the effect of
ACE inhibitors