AMFETAMINES AND FURAZOLIDONE

The pressor responses to dexamfetamine in 4 hypertensive patients were increased 2- to 3-fold after 6 days of furazolidone use, and after 13 days they had increased by about 10-fold. Furazolidone has MAO-inhibitory activity, after 5 to 10 days of use, which is about equivalent to that of the non-selective MAOIs.
Concurrent use with amfetamines may be expected to result in a potentially serious rise in blood pressure and should therefore be avoided.
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