The incidence of skin rashes among those taking either ampicillin or amoxicillin is increased by allopurinol.
There would seem to be no strong reason for avoiding concurrent use, but prescribers should recognise that the development of a rash is by no means unusual. Whether this also occurs with penicillins other than ampicillin or amoxicillin is uncertain, but it does not seem to have been reported.
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