ALCOHOL AND TETRACYCLINES

Doxycycline serum levels may fall below minimum therapeutic concentrations in alcoholic patients, but tetracycline is not affected. There is nothing to suggest that moderate amounts of alcohol have a clinically relevant effect on the serum levels of any tetracycline in non-alcoholic subjects.
Information is limited, but the interaction between doxycycline and alcohol appears to be established and of clinical significance in alcoholics. One possible solution to the problem of enzyme induction is to give alcoholic subjects double the dose of doxycycline. Alternatively tetracycline could be used because it appears not to be affected. There is nothing to suggest that moderate or even occasional heavy drinking has a clinically relevant effect on any of the other tetracyclines in non-alcoholic subjects.
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