Doxycycline
serum levels may fall below minimum therapeutic concentrations in alcoholic patients, but
tetracycline is not affected. There is nothing to suggest that moderate amounts of
alcohol have a clinically relevant effect on the
serum levels of any
tetracycline in non-alcoholic subjects.
Information is limited, but the interaction between doxycycline and
alcohol appears to be established and of
clinical significance in alcoholics. One possible solution to the problem of
enzyme induction is to give alcoholic subjects double the dose of doxycycline. Alternatively
tetracycline could be used because it appears not to be affected. There is nothing to suggest that moderate or even occasional heavy drinking has a clinically relevant effect on any of the other
tetracyclines in non-alcoholic subjects.