Although additive
CNS effects are possible, a study found no adverse interaction appears to occur if patients using transdermal
hyoscine (Scopoderm TTS) drink
alcohol.
In general, the manufacturers of several
hyoscine preparations suggest that
alcohol should be avoided, although note that
hyoscine butylbromide and
hyoscine methobromide do not readily pass the blood-brain barrier, and would not be expected to cause additive adverse effects with
alcohol.