Although additive CNS effects are possible, a study found no adverse interaction appears to occur if patients using transdermal hyoscine (Scopoderm TTS) drink alcohol.
In general, the manufacturers of several hyoscine preparations suggest that alcohol should be avoided, although note that hyoscine butylbromide and hyoscine methobromide do not readily pass the blood-brain barrier, and would not be expected to cause additive adverse effects with alcohol.
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