An isolated case report describes a very severe disulfiram-like reaction when a man taking
griseofulvin drank a can of beer. Two other patients taking
griseofulvin developed flushing and tachycardia after drinking. Several other patients have experienced an increase in the effects of
alcohol while taking
griseofulvin.
The documentation is extremely sparse, which would seem to suggest that adverse interactions between
alcohol and
griseofulvin are uncommon. At the risk of being over-cautious, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks.