An isolated case report describes a very severe disulfiram-like reaction when a man taking griseofulvin drank a can of beer. Two other patients taking griseofulvin developed flushing and tachycardia after drinking. Several other patients have experienced an increase in the effects of alcohol while taking griseofulvin.
The documentation is extremely sparse, which would seem to suggest that adverse interactions between alcohol and griseofulvin are uncommon. At the risk of being over-cautious, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks.
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