The combined effect of aspirin and alcohol on the stomach wall is established. Aspirin 3 g daily for a period of 3 to 5 days induces an average blood loss of about 5 mL. Some increased loss undoubtedly occurs with alcohol, but it seems to be quite small and unlikely to be of much importance in most healthy individuals using moderate doses of aspirin. In one study it was found that alcohol was a mild damaging agent or a mild potentiating agent for other gastrointestinal damaging drugs. It should be remem- bered that chronic and/or gross overuse of aspirin and alcohol may result in gastric ulceration. Other salicylates would be expected to have similar effects to aspirin.
This interaction is only likely to be of significance where high doses of aspirin or other oral salicylates are given to heavy drinkers.
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