Alpha blockers may enhance the hypotensive effect of alcohol in subjects susceptible to the alcohol flush syndrome. This appears to be rare in whites and blacks, but more common in Orientals. The serum levels of both indoramin and alcohol may be raised by concurrent use, which could lead to increased drowsiness.
The general significance of the hypotensive effects are unclear, but it may be prudent to warn susceptible patients when they start treatment. The degree of impairment caused by drinking alcohol whilst taking indoramin will depend on the individual patient. However, warn all patients of the potential effects, and counsel against driving or undertaking other skilled tasks. See also antihyperten- sives, for general comments about hypertension and alcohol consump- tion.
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