Abenol , A'Cenol, Acephen, Anacin-3, Anuphen, APAP, Atasol , Campain , Dolanex, Exdol , Halenol, Liquiprin, Panadol, Pedric, Robigesic , Rounox , Tapar, Tempra, Tylenol, Tylenol Arthritis, Valadol
Classifications: nonnarcotic analgesic, antipyretic; Therapeutic: nonnarcotic analgesic; antipyretic
Pregnancy Category: B
80 mg, 120 mg, 125 mg, 300 mg, 325 mg, 650 mg suppositories; 80 mg, 160 mg, 325 mg, 500 mg tablets/caplets; 650 mg extended release tablets/capsules; 80 mg/0.8 mL, 80 mg/2.5 mL, 80 mg/5 mL, 120 mg/5 mL, 160 mg/5 mL, 500 mg/5 mL liquid
Produces analgesia by unknown mechanism, but it is centrally acting in the CNS by increasing the pain threshold by inhibiting
cyclooxygenase. Reduces fever by direct action on hypothalamus heat-regulating center with consequent peripheral vasodilation,
sweating, and dissipation of heat. Unlike aspirin, has little effect on platelet aggregation, does not affect bleeding time,
and produces no gastric bleeding.
It provides temporary analgesia for mild to moderate pain. In addition, acetaminophen lowers body temperature in individuals
with a fever.
Fever reduction. Temporary relief of mild to moderate pain. Generally as substitute for aspirin when the latter is not tolerated
or is contraindicated.
Hypersensitivity to acetaminophen or phenacetin; use with alcohol.
Repeated administration to patients with anemia, G6PD deficiency, renal or hepatic disease; arthritic or rheumatoid conditions
affecting children <12 y; alcoholism; malnutrition; thrombocytopenia; bone marrow depression, immunosuppression; pregnancy
Route & Dosage
|Mild to Moderate Pain, Fever
Adult: PO 325650 mg q46h (max: 4 g/d) PR 650 mg q46h (max: 4 g/d)
Child: PO 1015 mg/kg q46h PR 25 y, 120 mg q46h (max: 720 mg/d); 612 y, 325 mg q46h (max: 2.6 g/d)
Neonate: PO 1015 mg/kg q68h
- Administer tablets or caplets whole or crushed and give with fluid of patient's choice.
- Chewable tablets should be thoroughly chewed and wetted before they are swallowed.
- Do not coadminister with a high carbohydrate meal; absorption rate may be significantly retarded.
- Store in light-resistant containers at room temperature, preferably between 15°30° C (59°86°
- Insert suppositories beyond the rectal sphincter.
Adverse Effects (≥1%)Body as a Whole:
Negligible with recommended dosage; rash. Acute poisoning:
Anorexia, nausea, vomiting, dizziness, lethargy, diaphoresis, chills, epigastric or abdominal pain, diarrhea; onset of hepatotoxicity
elevation of serum transaminases (ALT, AST) and bilirubin; hypoglycemia
, hepatic coma, acute renal failure
(rare). Chronic ingestion:
Neutropenia, pancytopenia, leukopenia, thrombocytopenic purpura, hepatotoxicity in alcoholics, renal
Diagnostic Test Interference
False increases in urinary 5-HIAA (5-hydroxyindoleacetic acid) by-product of serotonin; false decreases in blood glucose (by glucose oxidaseperoxidase procedure); false increases in urinary glucose (with certain instruments in glucose analyses); and false increases in serum uric acid (with phosphotungstate method). High doses or long-term therapy: hepatic, renal, and hematopoietic function (periodically).
may decrease acetaminophen absorption. With chronic coadministration, barbiturates
, carbamazepine, phenytoin,
may increase potential for chronic hepatotoxicity. Chronic, excessive ingestion of alcohol
will increase risk of hepatotoxicity.
Rapid and almost complete absorption from GI tract; less complete absorption from rectal suppository. Peak:
0.52 h. Duration:
34 h. Distribution:
In all body fluids; crosses placenta. Metabolism:
Extensively in liver. Elimination:
90100% of drug excreted as metabolites in urine; excreted in breast milk. Half-Life:
Assessment & Drug Effects
- Monitor for S&S of: hepatotoxicity, even with moderate acetaminophen doses, especially in individuals with poor nutrition
or who have ingested alcohol over prolonged periods; poisoning, usually from accidental ingestion or suicide attempts; potential
abuse from psychological dependence (withdrawal has been associated with restless and excited responses).
Patient & Family Education
- Do not take other medications (e.g., cold preparations) containing acetaminophen without medical advice; overdosing and
chronic use can cause liver damage and other toxic effects.
- Do not self-medicate adults for pain more than 10 d (5 d in children) without consulting a physician.
- Do not use this medication without medical direction for: fever persisting longer than 3 d, fever over 39.5° C (103°
F), or recurrent fever.
- Do not give children more than 5 doses in 24 h unless prescribed by physician.