Classifications: nasal decongestant; vasoconstrictor; Therapeutic: nasal decongestant
Pregnancy Category: C
0.05%, 0.1% nasal solution
Markedly constricts dilated arterioles of nasal membrane. Has little or no beta-adrenergic activity.
Decreases fluid exudate and mucosal engorgement associated with rhinitis and may open up obstructed eustachian tubes.
Temporary relief of nasal congestion associated with common cold, sinusitis, acute and chronic rhinitis, and hay fever and
Sensitivity to adrenergic substances; angle-closure glaucoma; concurrent therapy with MAO inhibitors or tricyclic antidepressants;
lactation, and infants; pregnancy (category C).
Hypertension; hyperthyroidism; heart disease, including angina; advanced arteriosclerosis, older adults, and children.
Route & Dosage
Adult/Child (≥12 y): Nasal 12 sprays or 12 drops of 0.1% solution in each nostril q810h (max: 3 doses/d)
Child (2 12 y): Nasal 1 spray or 23 drops of 0.05% solution in each nostril q810h (max: 3 doses/d)
- Have patient clear each nostril gently before administering spray or drops.
- Spray: Do not shake container. Hold tube vertically (spray end up) so that solution is delivered in a fine spray. Head should
be erect; spray into each nostril; 35 min later, clear (blow) nose thoroughly.
- Drops: Patient should be in a lateral, head-low position to permit application of drops to lower nostril surface. Have patient
remain in this position for 5 min, then apply drops to opposite nostril surface in same manner; or drops may be instilled
with patient in reclining position with head tilted back as far as possible.
- Store at 15°30° C (59°86° F) in a tight, light-resistant container.
Adverse Effects (≥1%)All:
Usually mild and infrequent; local stinging, burning, dryness and ulceration, sneezing, headache, insomnia
, drowsiness. With excessive use: Rebound nasal congestion
and vasodilation, tremulousness, hypertension, palpitations, tachycardia, arrhythmia, somnolence, sedation, coma.
May cause increase BP with guanethidine, methyldopa, mao inhibitors
may decrease effectiveness of nasal decongestant.
510 min. Duration:
Assessment & Drug Effects
- Evaluate for development of rebound congestion (see ADVERSE EFFECTS).
Patient & Family Education
- Prevent contamination of nasal solution and spread of infection by rinsing dropper and tip of nasal spray in hot water after
each use; restrict use to the individual patient.
- Note: Prolonged use can cause rebound congestion and chemical rhinitis. Do NOT exceed prescribed dosage and report to physician
if drug fails to provide relief within 34 d.
- Do NOT self-medicate with OTC drugs, sprays, or drops without physician's approval.
- Note: Excessive use by a child may lead to CNS depression.