| VITAMIN E (TOCOPHEROL)
Aquasol E, Vita-Plus E, Vitec
Classifications: vitamin; Therapeutic: vitamin e
Pregnancy Category: A within RDA
100 IU, 200 IU, 400 IU, 500 IU, 800 IU tablets; 100 IU, 200 IU, 400 IU, 1000 IU capsules; 15 IU/0.3 mL, 15 IU/30 mL liquid
A group of naturally occurring fat-soluble substances known as tocopherols. Alpha tocopherol, comprising 90% of the
tocopherols, is the most biologically potent. An antioxidant, it prevents peroxidation, a process that gives rise to free
radicals (highly reactive chemical structures that damage cell membranes and alter nuclear proteins).
Prevents cell membrane and protein damage, protects against blood clot formation by decreasing platelet aggregation, enhances
vitamin A utilization, and promotes normal growth, development, and tone of muscles.
To treat and prevent hemolytic anemia due to vitamin E deficiency in premature neonates; to prevent retrolental fibroplasia
secondary to oxygen treatment in neonates, and in treatment of diseases with secondary erythrocyte membrane abnormalities
(e.g., sickle cell anemia, and G6PD deficiency and as supplement in malabsorption syndromes). Used in patients on diets
containing large amounts of polyunsaturated fats for long periods and in the patient who abruptly discontinues such a diet.
Also used topically for dry or chapped skin and minor skin disorders.
Muscular dystrophy and a number of other conditions with no conclusive evidence of value. A component of many multivitamin
formulations and of topical deodorant preparations as an antioxidant.
Bleeding disorders; thrombocytopenia; concurrent administration with Coumadin.
Pregnancy (category A within RDA). Large doses may exacerbate iron deficiency anemia.
Route & Dosage
|Vitamin E Deficiency
Adult: PO/IM 6075 IU/d
Child: PO 1 IU/kg/d
Prophylaxis for Vitamin E Deficiency
Adult: PO 1215 IU/d
Child: PO 710 IU/d
Neonate: PO 5 IU/d
- Give on an empty stomach or following food or milk if GI upset occurs.
- Store in tight containers protected from light.
Adverse Effects (≥1%)Body as a Whole:
Skeletal muscle weakness, headache, fatigue
(with excessive doses). GI:
, intestinal cramps. Urogenital:
Gonadal dysfunction. Metabolic:
creatine kinase, cholesterol, triglycerides; decreased serum
thyroxine and triiodothyronine; increased urinary
estrogens, androgens; creatinuria. Skin:
Sterile abscess, thrombophlebitis, contact dermatitis. Special Senses:
InteractionsHerbal: Mineral oil, cholestyramine
may decrease absorption of vitamin E; may enhance anticoagulant activity of warfarin.
2060% absorbed from GI tract if fat absorption is normal; enters blood via lymph
Stored mainly in adipose tissue
; crosses placenta. Metabolism:
In liver. Elimination:
Primarily in bile.
Patient & Family Education
- If taking a large dose of iron, the RDA of vitamin E may be increased.
- Natural sources of vitamin E are found in wheat germ (the richest source) as well as in vegetable oils (sunflower, corn,
soybean, cottonseed), green leafy vegetables, nuts, dairy products, eggs, cereals, meat, and liver.