Classifications: hormone; gonadotropin-releasing hormone agonist analog; Therapeutic: gonadotropin-releasing hormone agonist analog
Prototype: Leuprolide acetate
Pregnancy Category: X
3.75 mg injection
Synthetic luteinizing releasing hormone agonist (LHRH or GnRH) with greater potency than naturally occurring luteinizing
hormone. Potent inhibitor of gonadotropin secretion. It causes decreased formation of testosterone.
In men, the level of serum testosterone is equivalent to a surgically castrated man.
Palliative treatment of advanced prostate cancer.
Hypersensitivity to triptorelin, other LHRH agonists, or LHRH; dysfunctional uterine bleeding; pregnancy (category X), lactation;
Prostatic carcinoma; hepatic or renal dysfunction; patients with impending spinal cord compression or severe urogenital
disorder; premenstrual syndrome; renal insufficiency.
Route & Dosage
Adult: IM 3.75 mg qmo
- Give deep into a large muscle.
Adverse Effects (≥1%) Body as a Whole: Hot flushes,
pain, leg pain, fatigue
Hypertension. GI: Diarrhea
, vomiting. Hematologic: Anemia
Skeletal pain. CNS:
Headache, dizziness, insomnia
, impotence, emotional lability. Skin:
Urinary retention, UTI. Other:
Pain at injection site.
Diagnostic Test Interference
May interfere with tests for pituitary-gonadal function.
13 h. Duration:
1 mo. Metabolism:
Eliminated by liver and kidneys. Half-Life:
Assessment & Drug Effects
- Monitor for S&S of disease flare, especially during the first 12 wk of therapy: Increased bone pain, blood in urine,
urinary obstruction, or symptoms of spinal compression.
- Lab tests: Periodic serum testosterone, PSA, acid phosphatase levels; urinary and serum calcium; urinary calcium/creatinine
ratio; lipid profile in those at risk for atherosclerosis.
Patient & Family Education
- Disease flare (see ASSESSMENT & DRUG EFFECTS) is a common, temporary adverse effect of therapy; however, symptoms may become serious enough to report to the physician.
- Notify physician promptly of the following: S&S of an allergic reaction (itching, hives, swelling of face, arms, or legs;
tingling in mouth or throat, tightness in chest or trouble breathing); weakness or loss of muscle control; rapid weight gain.