Trelstar Depot
Classifications: hormone; gonadotropin-releasing hormone agonist analog;
Therapeutic: gonadotropin-releasing hormone agonist analog

Prototype: Leuprolide acetate
Pregnancy Category: X


3.75 mg injection


Synthetic luteinizing releasing hormone agonist (LHRH or GnRH) with greater potency than naturally occurring luteinizing hormone. Potent inhibitor of gonadotropin secretion. It causes decreased formation of testosterone.

Therapeutic Effect

In men, the level of serum testosterone is equivalent to a surgically castrated man.


Palliative treatment of advanced prostate cancer.


Hypersensitivity to triptorelin, other LHRH agonists, or LHRH; dysfunctional uterine bleeding; pregnancy (category X), lactation; children.

Cautious Use

Prostatic carcinoma; hepatic or renal dysfunction; patients with impending spinal cord compression or severe urogenital disorder; premenstrual syndrome; renal insufficiency.

Route & Dosage

Prostate Cancer
Adult: IM 3.75 mg qmo


  • Give deep into a large muscle.

Adverse Effects (≥1%)

Body as a Whole: Hot flushes, pain, leg pain, fatigue. CV: Hypertension. GI: Diarrhea, vomiting. Hematologic: Anemia. Musculoskeletal: Skeletal pain. CNS: Headache, dizziness, insomnia, impotence, emotional lability. Skin: Pruritus. Urogenital: Urinary retention, UTI. Other: Pain at injection site.

Diagnostic Test Interference

May interfere with tests for pituitary-gonadal function.


Peak: 1–3 h. Duration: 1 mo. Metabolism: Unknown. Elimination: Eliminated by liver and kidneys. Half-Life: 3 h.

Nursing Implications

Assessment & Drug Effects

  • Monitor for S&S of disease flare, especially during the first 1–2 wk of therapy: Increased bone pain, blood in urine, urinary obstruction, or symptoms of spinal compression.
  • Lab tests: Periodic serum testosterone, PSA, acid phosphatase levels; urinary and serum calcium; urinary calcium/creatinine ratio; lipid profile in those at risk for atherosclerosis.

Patient & Family Education

  • Disease flare (see ASSESSMENT & DRUG EFFECTS) is a common, temporary adverse effect of therapy; however, symptoms may become serious enough to report to the physician.
  • Notify physician promptly of the following: S&S of an allergic reaction (itching, hives, swelling of face, arms, or legs; tingling in mouth or throat, tightness in chest or trouble breathing); weakness or loss of muscle control; rapid weight gain.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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