Classifications: antiviral; Therapeutic: antiviral
Pregnancy Category: C
1% ophthalmic solution
Pyrimidine nucleoside whose mechanism of antiviral action is not completely known but appears to involve inhibition of viral
DNA synthesis and viral replication.
Active against herpes simplex virus (HSV) types 1 and 2, vaccinia virus, and certain strains of adenovirus.
Topically to eyes for treatment of primary keratoconjunctivitis and recurring epithelial keratitis caused by herpes simplex
virus types 1 and 2. Also for other herpetic ophthalmic infections including stromal keratitis, uveitis, and for infections
caused by vaccinia and Adenovirus, but clinical effectiveness has not been established.
Pregnancy (category C), lactation; children <6 y.
Dry eye syndrome.
Route & Dosage
|Viral Infections of Eye
Adult: Ophthalmic 1 drop 1% ophthalmic solution into affected eye q2h during waking hours until healing (reepithelialization) has occurred
(max: 9 drops/d); when healing appears to be complete, dosage reduced to 1 drop q4h during waking hours for an additional
7 d (max: 5 drops/d); continuous administration beyond 21 d not recommended
- Wait several minutes between applications when used concurrently with other eye drops.
- Store refrigerated at 2°8° C (36°46° F) unless otherwise directed.
Adverse Effects (≥1%)Special Senses:
Mild transient burning or stinging, mild irritation of conjunctiva or cornea, photophobia, edema of eyelids and cornea,
punctal occlusion, superficial punctate keratopathy, epithelial keratopathy, stromal edema, keratitis sicca, hyperemia, increased
No clinically significant interactions established.
Following topical application to eye, trifluridine penetrates cornea and aqueous humor (inflammation enhances penetration).
Systemic absorption does not appear to be significant.
Assessment & Drug Effects
- Expect epithelial eye infections to respond to therapy within 27 d, with complete healing occurring in 12 wk.
Patient & Family Education
- Inform physician of progress and keep follow-up appointments. Herpetic eye infections have a tendency to recur and can lead
to corneal damage if not adequately treated.