TOREMIFENE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

The anticoagulant effects of acenocoumarol and warfarin are markedly increased by tamoxifen and bleeding has been seen. Toremifene is expected to interact similarly.
Monitor the effects closely if toremifene is added to treatment with warfarin or acenocoumarol and reduce the dosage as necessary. Note that the manufacturers contraindicate concurrent use (UK), or advise increased monitoring (US).