TICLOPIDINE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

In one study ticlopidine increased warfarin levels, although the INR appeared to be unchanged. There is some evidence that liver damage may occur in a small number of patients given warfarin with ticlopidine. The anticoagulant effects of acenocoumarol are modestly reduced by ticlopidine.
The manufacturers of ticlopidine strongly advise avoiding the concurrent use of anticoagulants because of the possible increased bleeding risks. If both drugs are essential they recommend monitoring the anticoagulant effect.