Classifications: coagulator, hemostatic, topical; Therapeutic: coagulator; hemostatic
Prototype: Aminocaproic acid
Pregnancy Category: C
1000, 5000, 10,000, 20,000, 50,000 unit vials
Plasma protein prepared from prothrombin of bovine origin. Induces clotting of whole blood or fibrinogen solution without
addition of other substances.
Facilitates conversion of fibrinogen to fibrin resulting in clotting of whole blood.
When oozing of blood from capillaries and small venules is accessible, as in dental extraction, plastic surgery, grafting
procedures, and epistaxis; also to shorten bleeding time at puncture sites in heparinized patient (i.e., following hemodialysis).
Known hypersensitivity to any of drug components or to material of bovine origin; parenteral use; entry or infiltration
into large blood vessels; pregnancy (category C).
Children and infants.
Route & Dosage
Adult: Topical 1002000 NIH U/mL, depending on extent of bleeding, may be used as solution, in dry form, by mixing thrombin with blood
plasma to form a fibrin "glue," or in conjunction with absorbable gelatin sponge
- Ensure that sponge recipient area is free of blood before applying thrombin.
- Prepare solutions in sterile distilled water or isotonic saline.
- Use solutions within a few hours of preparation. If several hours are to elapse between time of preparation and use, solution
should be refrigerated, or preferably frozen, and used within 48 h.
- Store lyophilized preparation at 2°8° C (36°46° F).
Adverse Effects (≥1%)Body as a Whole:
Sensitivity, allergic and febrile reactions, intravascular clotting and death when thrombin is allowed to enter large blood vessels.