Classifications: antiinfective, topical; antiseptic, topical; Therapeutic:topical antiseptic
Pregnancy Category: C
1:1000 solution, tincture, spray
Topical organic mercurial with sustained bacteriostatic and fungistatic activity. Ineffective against spore-forming organisms.
Utilized as a topical antiseptic because it is both a bacteriostatic and fungistatic agent.
First-aid treatment of contaminated wounds, in antisepsis of intact skin, before surgery, and in pustular dermatosis; as
antifungal agent in athlete's foot for wound irrigations. Ophthalmic preparation is used to treat conjunctivitis and corneal
ulcer and for prevention of infection following removal of foreign bodies. Used as preservative in most solutions sold for
cleaning, wetting, soaking, and storage of contact lenses; also used as preservative for biologic and pharmaceutical products.
History of sensitivity to thio or mercurial compounds; prolonged use; pregnancy (category C).
Route & Dosage
Adult: Topical 1:1000 solution, apply locally 13 times/d
- Clean before applying antiseptic for first-aid treatment.
- Do not apply bandage or other occlusive dressing until tincture application has completely dried in order to prevent skin
- Store in tightly covered, light-resistant containers. Avoid exposure to excessive heat.
Adverse Effects (≥1%)Skin:
, papular or vesicular eruptions. Body as a Whole:
Mercury poisoning with prolonged use (metallic taste, salivation, stomatitis
, lethargy, peripheral neuropathy
May have mercury absorption with prolonged use over large areas.
Assessment & Drug Effects
- Be aware that Aqueous Merthiolate contains thimerosal and borate (0.14%). Both are toxic if absorbed systemically.