SULFINPYRAZONE AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

The anticoagulant effects of warfarin and acenocoumarol are markedly increased by
sulfinpyrazone and serious bleeding has occurred.
The INR should be well monitored and suitable anticoagulant dosage reductions
made. Halving the dosage of warfarin and reducing the acenocoumarol dosage by
one-fifth has proven to be adequate in some patients.