SUCCINYLCHOLINE CHLORIDE ![]() (suk-sin-ill-koe'leen) ![]() Anectine, Quelicin Classifications: depolarizing skeletal muscle relaxant; Therapeutic: depolarizing skeletal muscle relaxant Pregnancy Category: C |
20 mg/mL, 50 mg/mL, 100 mg/mL injection
Synthetic, ultrashort-acting depolarizing neuromuscular blocking agent with high affinity for acetylcholine (ACh) receptor sites.
Initial transient contractions and fasciculations are followed by sustained flaccid skeletal muscle paralysis produced by state of accommodation that develops in adjacent excitable muscle membranes.
To produce skeletal muscle relaxation as adjunct to anesthesia; to facilitate intubation and endoscopy, to increase pulmonary compliance in assisted or controlled respiration, and to reduce intensity of muscle contractions in pharmacologically induced or electroshock convulsions.
Hypersensitivity to succinylcholine; family history of malignant hyperthermia; burns; trauma; pregnancy (category C).
During delivery by cesarean section; lactation; kidney, liver, pulmonary, metabolic, or cardiovascular disorders; myasthenia gravis; dehydration, electrolyte imbalance, patients taking digitalis, severe burns or trauma, fractures, spinal cord injuries, degenerative or dystrophic neuromuscular diseases, low plasma pseudocholinesterase levels (recessive genetic trait, but often associated with severe liver disease, severe anemia, dehydration, marked changes in body temperature, exposure to neurotoxic insecticides, certain drugs); collagen diseases, porphyria, intraocular surgery, glaucoma; lactation.
Surgical and Anesthetic Procedures Adult: IV 0.31.1 mg/kg administered over 1030 sec, may give additional doses prn IM 2.54 mg/kg up to 150 mg Child: IV 12 mg/kg administered over 1030 sec, may give additional doses prn IM 2.54 mg/kg up to 150 mg Prolonged Muscle Relaxation Adult: IV 0.510 mg/min by continuous infusion Obesity Dose based on IBW. |
Intravenous
PREPARE: Direct: Give undiluted. Intermittent/Continuous: Dilute 1 g in 5001000 mL of D5W or NS. ADMINISTER: Direct: Give a bolus dose over 30 sec. Intermittent/Continuous: Preferred. Give at a rate of 0.510 mg/min. Do not exceed 10 mg/min. INCOMPATIBILITIES Solution/additive: Aminophylline, ampicillin, cephalothin, diazepam, epinephrine, hydrocortisone, methicillin, methohexital, nitrofurantoin, oxacillin, oxytetracycline, sodium bicarbonate, thiopental, warfarin. Y-site: Thiopental. |
Assessment & Drug Effects
Patient & Family Education