The concurrent use of a triptan and an SSRI is normally uneventful, but adverse reactions (such as
serotonin syndrome, reported with
sumatriptan and some SSRIs) do occasionally occur. Fluvoxamine has been shown to increase the blood levels of
frovatriptan by 27 to 49%, and is predicted to increase the levels of
zolmitriptan.
The combination need not be avoided, but monitor carefully, especially if other serotonergic drugs are also used. The manufacturers of
zolmitriptan recommend a dosage reduction to a maximum of 5 mg in 24 hours in the presence of
fluvoxamine.