SSRIS AND TRAZODONE

Trazodone and fluoxetine have been used concurrently with advantage, although fluoxetine may modestly increase the levels of trazodone and some patients may develop increased adverse effects. Additive adverse effects such as sedation are predicted to possibly occur with other SSRIs.
It may be prudent to monitor for excessive sedation when trazodone is used with an SSRI.