Fluvoxamine can increase the AUC of
tacrine by up to 8-fold.
Tacrine adverse effects (nausea, vomiting, diarrhoea, sweating) are increased.
A decrease in the
tacrine dose is likely to be needed. Other
SSRIs such as fluoxetine,
paroxetine, or sertraline may be suitable alternatives, as these are unlikely to inhibit
tacrine metabolism.