| SODIUM FERRIC GLUCONATE COMPLEX
(so'di-um fer'ric glu'co-nate)
Classifications: blood former; iron preparation; Therapeutic: antianemic; iron replacement
Prototype: Ferrous sulfate
Pregnancy Category: B
62.5 mg elemental iron/5 mL ampule
Stable iron complex used to restore iron loss in chronic kidney failure patients. The use of erythropoietin therapy and
blood loss through hemodialysis require iron replacement. The ferric ion combines with transferrin and is transported to
bone marrow where it is incorporated into hemoglobin.
Effectiveness indicated by improved Hgb and Hct, iron saturation, serum ferritin levels.
Treatment of iron deficiency in patients on chronic hemodialysis and receiving erythropoietin therapy.
All anemias not related to iron deficiency; hypersensitivity to sodium ferric gluconate complex, benzyl alcohol; hemochromatosis,
hemosiderosis; hemolytic anemia; thalassemia; neonates.
Active or suspected infection; cardiac disease; hepatic disease; pregnancy (category B), lactation; older adults. Safety
and efficacy in children <6 y are not established.
Route & Dosage
|Iron Deficiency in Dialysis Patients
Adult: IV 125 mg infused over 1 h
Child (>6 y): IV 1.5 mg/kg infused over 1 h (max:125 mg/dose)
PREPARE: Direct for Adult: May be given undiluted. IV Infusion for Adult/Child: Dilute 125 mg in 100 mL of NS. Use immediately after dilution.
ADMINISTER: Direct for Adult: Give no faster than 12.5 mg/min. IV Infusion for Adult/Child: Give over NOT less than 60 min.
INCOMPATIBILITIES Solution/additive: Do not mix with any other medications or add to parenteral nutrition solutions.
- Store unopened ampules at 20°25° C (68°77° F).
Adverse Effects (≥1%)Body as a Whole: Hypersensitivity reaction (cardiovascular collapse, cardiac arrest, bronchospasm, oral/pharyngeal edema, dyspnea
urticaria, pruritus). CV:
Assessment & Drug Effects
- Monitor closely for S&S of severe hypersensitivity (see Appendix F) during IV administration.
- Monitor vital signs periodically during IV administration (transient hypotension possible especially during dialysis).
- Stop infusion immediately and notify physician if hypersensitivity is suspected.
- Lab tests: Periodic Hgb, Hct, Fe saturation, serum ferritin.
Patient & Family Education
- Report to physician immediately: Difficulty breathing, itching, flushing, rash, weakness, light-headedness, pain, or any
other discomfort during infusion.