| SILVER SULFADIAZINE
Classifications: sulfonamide; Therapeutic: topical antiinfective
Pregnancy Category: B
1%/50 g cream
Silver salt is released slowly and exerts bactericidal effect only on bacterial cell membrane and wall, rather than by inhibiting
folic acid synthesis; antibacterial activity is not inhibited by p-aminobenzoic acid (PABA).
Broad antimicrobial activity including many gram-negative and gram-positive bacteria and yeast.
Prevention and treatment of sepsis in second- and third-degree burns.
Hypersensitivity to other sulfonamides; pregnant women at term, premature infants and neonates <1 mo.
Impaired kidney or liver function; porphyria; impaired respiratory function; G6PD deficiency; thrombocytopenia, leukopenia,
hematological disease; pregnancy (category B), lactation.
Route & Dosage
|Burn Wound Treatment
Adult/Child: Topical Apply 1% cream 12 times/d to thickness of approximately 1.5 mm (1/16 in.)
- Do not use if cream darkens; it is water soluble and white.
- Apply with sterile, gloved hands to cleansed, debrided burned areas. Reapply cream to areas where it has been removed by
patient activity; cover burn wounds with medication at all times.
- Bathe patient daily (in whirlpool or shower or in bed) as aid to debridement. Reapply drug.
- Note: Dressings are not required but may be used if necessary. Drug does not stain clothing.
- Store at room temperature away from heat.
Adverse Effects (≥1%)Body as a Whole:
Pain (occasionally), burning, itching, rash, reversible leukopenia. Potential for toxicity as for other sulfonamides if
applied to extensive areas of the body surface.
InteractionsDrug: proteolytic enzymes
are inactivated by silver in cream.
Not absorbed through intact skin, however, approximately 10% could be absorbed when applied to second- or third-degree
Distributed into most body tissues. Metabolism:
In the liver. Elimination:
Assessment & Drug Effects
- Observe for and report hypersensitivity reaction: Rash, itching, or burning sensation in unburned areas.
- Lab tests: Obtain serum sulfa concentrations, urinalysis, and kidney function tests when drug is applied to extensive areas.
Significant quantities of drug may be absorbed.
- Observe patient for reactions attributed to sulfonamides.
- Note: Analgesic may be required. Occasionally, pain is experienced on application; intensity and duration depend on depth of burn.
- Continue treatment until satisfactory healing or burn site is ready for grafting, unless adverse reactions occur.